"I'm over the moon, absolutely over the moon," she said. "I can't believe I've won an EPT."
The 25-year-old University of Manchester graduate once worked as a video host on Virgin Media's EPT coverage and got her start in the game on a poker reality game show where she was schooled by the likes of Phil Hellmuth, Annie Duke and Dave "Devilfish" Ulliott.
Previously, Boeree won the 2008 European Ladies Championships and went deep in the 2009 WPT Championship, but Wednesday's €1,250,000 win was by far the largest score of her career.
"This is exactly what I've been working for since I learned poker, winning a major event," she said. "The entire tournament I had such a weird feeling I was going to win it. I didn't tell anyone. I'm a scientist, so I try not to get weird like that. This is all just a big blur. I can't believe I have won. I really played my arse off."
A total of 1,240 players from 44 different countries entered the €5,000+€300 Italian tournament, making it the biggest EPT ever.
Boeree went into the final table fifth in chips trailing massive chip leader Jakob Carlsson by what appeared to be an insurmountable figure.
However, by the time she had worked her way into a heads-up match for the title with the 22-year-old Swede, Boeree was in the driver's seat.
Carlsson chipped his way back into the lead, but Boree turned a wheel against his flopped pair of aces to win a big pot and take control again.
Despite an ill-timed dinner break halting her momentum, Boeree returned and cruised to victory.
She says she's put a lot of hours into her game and it paid dividends this week in San Remo.
"I have been working a lot on my game," she said. "I had a lot of work to do.
"Jakob was the person I really didn't want to get heads-up against, but I just played my arse off. It's just incredible. I won my way into the event in a €500 satellite."
Looking forward, Boeree says she'll be taking care of her new found riches.
"I will invest the money wisely," she said. "I'm not going to just hit the craps table. I'm going to buy a nice car, and buy a house, maybe two houses.
"I'm also going to buy a new guitar and a new amp and make a lot of noise in my new house."
PokerListings has been following Boeree's career from the start. For coverage highlights check out our blog saluting her.