"We destroyed them," said European captain Annette Obrestad. "They had no chance."
The made-for-TV tournament held at Casino at the Empire began with an odd brand of team poker where partners on either side of the table swapped control on each street.
Europe grabbed a 2-0 lead when they got it in with ace-three against pocket aces and managed to suck out a straight.
However, the European team took a commanding 3 to 1 lead when Denmark's Gus Hansen and Peter Eastgate beat John Juanda and Barry Greenstein, the latter running king-jack into ace-ten and failing to improve.
The format moved to heads-up next with Obrestad taking on Seed.
The young Norwegian took control after getting it all in with middle-pair-top-kicker against Seed's pair and a flush draw and managed to hold.
The match and the event were over soon after when Seed found himself all in with a dominated ace.
An ecstatic Obrestad said her decision to value youth over experience in choosing teammates for the event proved the right one.
"I would say that we outplayed them for the most part," she said. "We didn't make that many mistakes at all and we didn't get that lucky.
"The thing is in Europe there are not that many professional poker players like they have in the States. We don't have any Doyle Brunsons in Europe. Most of the guys who are experienced are young."
Negreanu saw things a little differently.
"Two things," he said. "First of all, in all the key situations, whether it was an ace versus an ace or whatever, they won every one of those. A lot of the key hands we just got unlucky in.
"Secondly, the specific format really didn't allow players, like Phil Ivey for example, to exhibit his strengths. It was all-in poker."
Coverage of the event will air on ESPN in the new year.