He finally got over the hump and won the whole thing.
Seed had made it to the semifinals two out of the first four years at this event.
Now, with the addition of this win to his Heads-Up title at the 2008 Canadian Open Poker Championship, Seed has cemented his status as one of the best heads-up players in the world.
Although the humble 1996 Jonathan Little, Gus Hansen, Glen Chorny, David Oppenheim and Sam Farha en route to the finals.
Once there, he beat Vanessa Rousso two straight in the best-of-three finals format to take the title and its $500,000 first-place prize.
"I kind of felt one step ahead the whole way," he said of the match with Rousso, who turned a lot of heads in Las Vegas this weekend by becoming the first woman to go that deep at NBC Heads-Up.
In the process, Rousso beat the likes of Doyle Brunson, Phil Ivey, Paul Wasicka, Daniel Negreanu, and Bertrand "ElkY" Grospellier along the way.
The NBC National Heads-Up Championship has been criticized in the past for a speedy structure that can allow luck to become a big factor in the outcome, but Seed disagrees with the event's detractors.
"I think there's a lot of skill," he said. "Obviously not as much skill as if you played someone heads-up all day for like a week, or the durrrr Challenge, you know, 50,000 hands heads-up.
"Obviously that's an insanely [greater] amount of skill. But I think it's live poker; you can see the person and there's a lot of skill in each hand. I think there's a significant amount of skill involved here."
Farha proved the toughest test for Seed along the way, as he was on the brink of elimination in their semifinal match several times.
"My match against Sammy, I was kind of low on energy," he said. "I was getting frustrated, a little stiff in the chair."
Moments after hoisting the trophy, an exhausted Seed said he was ready to call it a night.
"I got up pretty early," he said. "I went to bed at 9:30 last night so I'm up past my bedtime today."
For a full recap of all the action in the 64-person event check out PokerListings' Live Updates.